Hydrocodone physicians desk reference

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Moderate The use of these drugs together must be approached with caution.

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Mitotane, a strong inducer of CYP3A4, may cause increased clearance of hydrocodone, which could result in lack of efficacy or the development of an abstinence syndrome in a patient who had developed physical dependence to hydrocodone. Also, impairment of CYP2D6 metabolism by sertraline may reduce the conversion of hydrocodone to its active forms, thus reducing analgesic efficacy. Etravirine, an inducer of CYP3A4, may cause increased clearance of hydrocodone, which could result in lack of efficacy or the development of an abstinence syndrome in a patient who had developed physical dependence to hydrocodone.

Addiction may occur in patients who obtain hydrocodone illicitly or in those appropriately prescribed the drug.

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Do not exceed recommended dosage limits for the specific product prescribed. Acetaminophen AUC, Cmax, and Tmax were not significantly changed when acetaminophen was given 1 h before exenatide injection. Use chlorpheniramine; hydrocodone; pseudoephedrine with caution in patients with adrenal insufficiency i. Consider the patient's use of alcohol or illicit drugs.

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Minor Theoretically, apraclonidine might potentiate the effects of CNS depressant drugs such as opiate agonists. Major Monitor for respiratory depression, sedation and decreased analgesic effect if hydrocodone and amiodarone are coadministered; consider dosage adjustments if necessary.

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Drugs that may cause additive CNS effects include trazodone. Ethinyl Estradiol; Norethindrone Acetate: Busulfan is metabolized in the liver through conjugation with glutathione; acetaminophen decreases glutathione levels in the blood and tissues and may reduce the clearance of busulfan. Severe symptoms may require pharmacologic therapy managed by clinicians familiar with neonatal opioid withdrawal. Clinicians should be alert to changes in the effect of the opioid agonist.

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Opioid agonists may obscure the diagnosis or clinical course in patients with acute abdomen. Patients presenting with signs or symptoms of androgen deficiency should undergo laboratory evaluation. If administered, antihistamines should be used in the smallest possible dose in individuals who are susceptible to anticholinergic side effects or who are receiving other medications with anticholinergic properties.

Advise patients to get immediate medical attention for an acetaminophen overdose. Thus, these drugs can antagonize the beneficial actions of bethanechol on GI motility. Moderate Use caution if coadministration of ribociclib with hydrocodone is necessary, as the systemic exposure of hydrocodone may be increased resulting in an increase in treatment-related adverse reactions including sedation and respiratory depression; adjust the dose of hydrocodone if necessary.

Moderate Loxapine can potentiate the actions of other CNS depressants such as opiate agonists.

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Although salicylates are rarely associated with nephrotoxicity, high-dose, chronic administration of salicylates combined other analgesics, including acetaminophen, significantly increases the risk of analgesic nephropathy, renal papillary necrosis, and end-stage renal disease.

Theoretically, coadministration of hydrocodone and a CYP2D6 inhibitor, such as peginterferon alfa-2b, may result in a reduction in the analgesic effect of hydrocodone.

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