Clarithromycin dosage and administration

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Major In a study involving 6 HIVinfected patients, coadministration of delavirdine mg 3 times daily with clarithromycin mg twice daily resulted in no significant change in delavirdine pharmacokinetics.

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Clarithromycin tablets have been associated with prolongation of the QT interval and infrequent cases of arrhythmia. In these immunocompromised patients, evaluations of laboratory values were made by analysing those values outside the seriously abnormal level i.

Administration of clarithromycin has resulted in prolongation of the QT interval and TdP. Dosage and Administration Clarithromycin extended-release tablets should be taken with food. This week trial enrolled patients with AIDS and dMAC, with 55 patients randomized to receive Clarithromycin and ethambutol, and 51 patients randomized to receive Clarithromycin, ethambutol, and clofazime. Long-term studies in animals have not been performed to evaluate the carcinogenic potential of clarithromycin.

In clinical trials, elderly patients did not have an increased incidence of adverse events when compared to younger patients. Coadministration is contraindicated in patients with renal or hepatic impairment because colchicine accumulation may be greater in these populations.

To view formulary information first create a list of plans. Date of revision of the text. Compared to prior experience with Clarithromycin monotherapy, the two-drug regimen of Clarithromycin and ethambutol extended the time to microbiologic relapse, largely through suppressing the emergence of Clarithromycin resistant strains.

Distribution Distributed widely into most body tissues except central nervous system CNS Protein bound: Serious adverse reactions have been reported in patients taking Clarithromycin tablets concomitantly with CYP3A4 substrates. If a breast-feeding baby experiences an adverse effect related to a maternally ingested drug, healthcare providers are encouraged to report the adverse effect to the FDA.

The microbiologically active metabolite hydroxyclarithromycin is formed by first pass metabolism as indicated by lower bioavailability of the metabolite following IV administration. The use of Clarithromycin with simvastatin, lovastatin, ergotamine, or dihydroergotamine is contraindicated [see Contraindications 4.

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For the full list of excipients, see section 6. Refer to dosage regimens for mycobacterial infections in pediatric patients for additional dosage information [see Dosage and Administration 2.

A report of I ntermediate I indicates that the result should be considered equivocal, and, if the microorganism is not fully susceptible to alternative, clinically feasible drugs, the test should be repeated. In vitro studies have shown that dasatinib has the potential to prolong cardiac ventricular repolarization prolong QT intervaland clarithromycin is established to have a causal association with QT prolongation and TdP.

In hospital-acquired pneumonia, clarithromycin should be used in combination with additional appropriate antibiotics.

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Clarithromycin tablets, USP mg are white, oval-shaped, film-coated tablets, debossed GG C9 on one side and plain on the reverse side, and are supplied as follows:. Currently, macrolides are only considered to play a role in some skin and soft tissue infections, such as those caused by Corynebacterium minutissimum erythrasmaacne vulgaris, and erysipelas and in situations where penicillin treatment cannot be used.

Clarithromycin is associated with an established risk for QT prolongation and TdP while QT prolongation and TdP have been reported during postmarketing use of fluvoxamine.

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Name of the medicinal product 2. See Table 2 for dosage adjustment in patients with moderate or severe renal impairment with or without concomitant atazanavir or ritonavir-containing regimens [see Drug Interactions 7 ]. Psychotic disorder, confusional state, depersonalization, depression, disorientation, manic behavior, hallucination, abnormal behavior, abnormal dreams.

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