Digoxin electrophysiological effects
According to Withering, digitalis was believed to slow heart rate in patients with irregular pulse and result in diuresis. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide.
None had a known history of AF. This is then followed by a gradual decrease of action potential duration to less than control length. NO generated within the cardiomyocytes can exert intracrine effects or modify the functional properties of adjacent cardiomyocytes.
Effectiveness of digoxin in reducing one-year mortality in chronic heart failure in the digitalis investigation group trial. Sign In or Create an Account. Digoxin is commonly marketed under the trade names Lanoxin, Digitek, and Lanoxicaps. Adam StrickbergerFred Morady. Arlock P, Katzung BG Effects of sodium substitutes on transient inward current and tension in guinea-pig and ferret papillary muscle.
Pacing was performed with a programmable stimulator EPMedSystems. Are you a visual learner interested in learning psychopharmacology?
Isenberg G Is potassium conductance of cardiac Purkinje fibres controlled by [Ca21? More on this topic Pharmacological possibilities for protection against myocardial reperfusion injury. In conclusion, digoxin potentiates the shortening of atrial ERP and predisposition toward further episodes of AF that occurs after a short episode of AF. Donors of nitric oxide mimic effects of ischaemic preconditioning on reperfusion induced arrhythmias in isolated rat heart.
Digoxin resulted in a greater degree of shortening of the atrial ERP after a brief episode of AF and enhanced the heightened predisposition toward the reinduction of AF that was observed on conversion to sinus rhythm.
As illustrated in Figure 2, this effect can be therapeutic in that it can increase cardiac output sufficiently to allow adequate perfusion of vital organs, including the kidney. Neuronal nitric oxide synthase protects against myocardial infarction-induced ventricular arrhythmia and mortality in mice. On the multiple wavelet hypothesis of atrial fibrillation.
In this paper we review the effects of cardiac glycosides on the electrophysiological properties of mammalian cardiac muscle. Discussion Main Findings The results of this study demonstrate that the acute effects of a several-minute episode of AF on the electrophysiological properties of the atrium are accentuated by digoxin.
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NO produces contradictory effects on I Caincreasing, 16 decreasing, 1317—24 or producing a biphasic effect. The Pathophysiologic Basis of Drug Therapy, 2nd edition. High ventricular rates may also result in myocardial ischemia in patients having coronary artery disease and coronary insufficiency.
In response to this rise, the SR of the digoxin-treated cell sequesters more calcium.