Phenytoin is primarily metabolized to its inactive form by the enzyme CYP2C9. Nystagmus Nystagmus is a condition where the eyes make rapid, repetitive and uncontrolled movements. A study by the National Institutes of Health showed that antacids administered concomitantly with phenytoin "altered not only the extent of absorption but also appeared to alter the rate of absorption. Effects consist of the following: Chronic phenytoin use has been associated with decreased bone density and increased bone fractures.
Show More Related Topics. Retrieved 20 April Sleep Disorders Associated with Epilepsy Epilepsy and sleep disorders have a profound effect on each other.
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Complete the form below to receive the no-obligation price quote. Guidelines for Referral and Diagnosis. Tell your doctor if you are breastfeeding or plan to breastfeed. Phenytoin is also associated with induction of reversible IgA deficiency. Asked 30 Dec by faroo Active 5 Jan Topics seizuresstatus epilepticusepilepsycarbamazepinephenytoin.
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Phenytoin binds preferentially to the inactive form of the sodium channel. Folate is presented in foods as polyglutamate, which is then converted into monoglutamates by intestinal conjugase. HELLP syndrome is a rare but serious complication that affects pregnant women.
Before you take DILANTIN, inform your doctor or pharmacist of all the medications you take including prescription and over-the-counter medicines and any medical conditions you have including if you: Phenytoin is marketed under many trade names worldwide. Bruise easily Purple or red spots on your skin Increased infections.
Because it takes time for the bound drug to dissociate from the inactive channel, there is a time dependent block of the channel. Still looking for answers?
When will they stop? Journal of Toxicology and Environmental Health.