Dapsone gel 5 treatment acne vulgaris
Dapsone is an antibiotic that has been used since the s for the treatment of leprosy and skin disorders such as dermatitis herpetiformis and nodulocystic acne.
Better navigate the business aspects of medicine and stay on top of the changing healthcare landscape. Its first clinical use was discovered inwhen it was found to be efficacious in inhibiting the progression of leprosy. Expert Perspective Follow experts from across more than 30 medical specialties who share their viewpoints and guidance on medical developments as they unfold. Primary Care for Children with Autism. Reprints are not available from the author.
Osteoarthritis of the Hip Next: This is higher than the cost of a g tube of tretinoin Retin-A 0. Am J Clin Dermatol. Dapsone gel is FDA pregnancy category C; safety has not been established in breastfeeding mothers.
The potential of oral dapsone to treat acne vulgaris is well established, but the risks of serious side effects have made it an undesirable drug for use in the relatively healthy acne population. Accessed June 1, Courses were developed especially for physicians by business health experts and experienced physicians.
It is well tolerated, with pharmacokinetic evidence indicating topical dosing in comparison to oral administration significantly reduces systemic concentrations of the drug, and therefore risk of serious side effects. The aims of this study were to review the published literature on dapsone pharmacology and pharmacokinetics, and to evaluate the gel's efficacy and safety in treating acne vulgaris, and finally to provide personal insight into its future as a topical agent for acne vulgaris.
As dapsone is administered topically, it was expected that systemic absorption would be considerably lower than that observed with oral dapsone therapy, thereby avoiding any adverse haematological effects. Hemolytic anemia has been shown not to occur in patients with G6PD deficiency with acne who were treated with topical therapy. Two studies show a clinical success rate of Adverse effects of dapsone gel therapy occur mainly at the site of application.
This material may not otherwise be downloaded, copied, printed, stored, transmitted or reproduced in any medium, whether now known or later invented, except as authorized in writing by the AAFP.