Phenytoin (dilantin) is available in which dosage form
Phenytoin was negative in the Ames test and in the in vitro clastogenicity assay in Chinese hamster ovary CHO cells.
The lethal dose in pediatric patients is not known. Adjust the dosage to suit individual requirements up to a maximum of two capsules three times a day.
Print this page Add to My Med List. Due to an increased fraction of unbound phenytoin in patients with hepatic disease, the interpretation of total phenytoin plasma concentrations should be made with caution. Associated with exacerbation of porphyria; exercise caution when used in patients with this disease. Avoid drinking alcohol while you are taking this medicine. Individual drug package inserts should be consulted.
The initial symptoms are nystagmusataxiaand dysarthria. In adults, if seizure control is established with divided doses of three mg Dilantin capsules daily, once-a-day dosage with mg of extended phenytoin sodium capsules may be considered.
In these patients with acute hepatotoxicity, phenytoin should be immediately discontinued and not re-administered. Although approved for IM use, IM administration is not recommended, due to erratic absorption and pain on injection; fosphenytoin may be considered IV: However, cardiac events have also been reported in adults and children without underlying cardiac disease or comorbidities and at recommended doses and infusion rates.
Increased frequencies of major malformations such as orofacial clefts and cardiac defectsminor anomalies dysmorphic facial features, nail and digit hypoplasiagrowth abnormalities including microcephalyand mental deficiency have been reported among children born to epileptic women who took phenytoin alone or in combination with other antiepileptic drugs during pregnancy.
Other Restrictions Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
Usual Adult Dose for Seizures
Seizure control is very important during pregnancy and the benefits of preventing seizures may outweigh any risks posed by using phenytoin. The primary site of action appears to be the motor cortex where spread of seizure activity is inhibited. By clicking send, you acknowledge that you have permission to email the recipient with this information. Daily alcohol use can decrease your blood levels of phenytoin, which can increase your risk of seizures.
As phenytoin is highly protein bound, free phenytoin levels may be altered in patients whose protein binding characteristics differ from normal. Contact the applicable plan provider for the most current information. Hemodialysis can be considered since phenytoin is not completely bound to plasma proteins.
For most adults, the satisfactory maintenance dosage will be one capsule three to four times a day. The diluted infusion mixture Dilantin plus normal saline should not be refrigerated. Appropriate diagnostic procedures should be performed as indicated. The free acid form of phenytoin is used in Dilantin Suspension and Dilantin Infatabs.
Experience for periods greater than one week is lacking and blood level monitoring is recommended. Phenytoin sodium is an antiepileptic drug.