Hypericum and warfarin

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Unintended pregnancy has not been reported but, given the mechanism involved, there are grounds for concern that the interaction might reduce the contraceptive efficacy of some oestrogen-containing Oral Contraceptives. Avoid those Winter Blues!

Interactions with St. John's Wort (Hypericum perforatum) Preparations

There is strong evidence to suggest that St John's Wort significantly reduces the plasma concentrations of the following medicines:. The evidence to support these concerns ranges from specific clinical studies to reports of individual cases or is based on theoretical considerations. According to researchers, extracts of the plant administered under the careful supervision of a doctor can efficiently mimic the beneficial effects of regular antidepressant medication without the side effects.

Your use of this website and the information contained herein is subject to our Website Terms and Conditions and Privacy Policy. The degree of interaction with prescribed medicines may also vary. For instance, hypericin and hyperforin promote the release of dopamine, norepinephrine and serotonin, neurotransmitters that modulate signals between brain cells in view of an optimal brain activity. It is also quite toxic for livestock. Check theophylline levels and review use of SJW.

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Related information St John's Wort Hypericum perforatum. To date, one case of the interaction with cyclosporin and six cases of the interaction with reuptake inhibitor drugs have been reported in Australia. For some of the medicines listed there is at present no more than a theoretical possibility of interaction. A recently published study 1 found a clinically significant reduction in serum levels of indinavir, a protease inhibitor used to treat HIV infection, when it was used with a St John's wort preparation.

SSRIs and related antidepressants citalopram, fluoxetine, fluvoxamine, paroxetine, sertraline, nefazodone. It is important to note that when patients stop taking a preparation containing St John's Wort, plasma concentrations of interacting medicines may rise and result in toxicity. Anticonvulsant levels may increase on stopping SJW. Center for Medicare and Medicaid Services. The table gives an indication of the nature and strength of the evidence of interaction, describes the effect of an interaction should it occur, and provides advice on the management of patients.

Because St John's Wort preparations are so widely available, patients may be taking them without their health practitioner's knowledge. A copy of the information sheet is available on the TGA website.

Why do St John's wort preparations interact with other medicines?

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This Site Using Profiling Cookies. Hence, for some conditions the table advises discontinuing St John's wort.

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Copies were posted to general practitioners, selected specialists, community and hospital pharmacies, and complementary healthcare practitioners and retailers on 31 March Copies of the reporting form can be obtained from the Centre at the above address or can be downloaded from this web site.


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