Sodium alginate of low viscosity 0. The peaks at and cm -1 belong to the N-H stretching of the amide and ether bonds and N-H stretching amide III bandrespectively.
Carried out at ambient temperature, preparation is simple, rapid, and reliable. On the basis of previous work about chitosan hydrogels 18 - 20chitosan-alginate nanoparticles were prepared by ionotropic pre-gelation of an alginate core followed by chitosan polyelectrolyte complexation.
Nifedipine is used to treat high blood pressure and to control angina chest pain. The active substance of this investigation, nifedipine NFis an oral calcium-blocking agent used in the treatment of angina pectoris and hypertension; although it is absorbed almost completely, it displays a low bioavailability because of its short biological half-life with significant fluctuations in plasma concentrations 16 and its extensive first-pass metabolism Preparation and physico-chemical characterization.
If you become pregnant while taking nifedipine, call your doctor. Your doctor may prescribe a different medication to take when you have chest pain.
Sathya SeeliS. It controls chest pain by increasing the supply of blood and oxygen to the heart.
How should this medicine be used?
How does Europe PMC derive its citations network? Therefore, after incorporation of the CS to the calcium alginate pre-gel containing the nifedipine nanocrystals, calcium alginate pre-gel in the form of discrete nanoparticles simultaneously entrapping the nifedpine nanocrystals suspended in the medium.
Be sure to mention any of the following: Do not let anyone else take your medication. What special dietary instructions should I follow? Chitosan-sodium alginate nanoparticles as submicroscopic reservoirs for ocular delivery: Overview Side Effects Dosage More. It is important to keep all medication out of sight and reach of children as many containers such as weekly pill minders and those for eye drops, creams, patches, and inhalers are not child-resistant and young children can open them easily.
Protect from light and moisture; avoid freezing. Protein release from alginate matrices. Nifedipine was quantified by peak area measurement. To establish the nifedipine release profiles from nanoparticles at simulated gastric fluid pH1.