Warfarin and synthroid interaction
Drugs that increase metabolism of levothyroxine, lowering blood levels Enzyme inducers stimulate the production of enzymes, which in turn increase levothyroxine from the body.
Patients and Caregivers Clinician Explanation. Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. The interaction between warfarin and thyroid replacement is one of the most frequent alerts provided to pharmacists by computerized drug interaction systems, so it is important to assess any new information on this interaction.
New information suggests that even when the patient is on the warfarin first, severe hemorrhage is unlikely. Share on LinkedIn Share. J Am Med Inform Assoc. Historically, we have held that the interaction between warfarin and thyroid would rarely be clinically important, because the patient is usually taking thyroid first, and is then titrated on warfarin to the appropriate anticoagulation level. Studies Support Its Value.
Subscribe to the WebMD Daily, and you'll get today's top health news and trending topics, and the latest and best information from WebMD. The lack of change in the warfarin dose: It is important to tell your doctor about all other medications you use, including vitamins and herbs.
When they compared study subjects with controls patients taking warfarin who did not have levothyroxine addedthey found no increase in the risk of hospitalization due to hemorrhage. Raloxifene EVISTAused to treat osteoporosis, may reduce the absorption of levothyroxine, although the evidence to date is not sufficient to establish the extent of the interaction.
To view content sources and attributions, please refer to our editorial policy. However, no special precautions are necessary if patients have been stable on levothyroxine therapy and are currently starting therapy with warfarin. One hundred and two patients were included in the primary outcome.
All generic drug interactions for warfarin oral lists will include brand and generic names:.
One study found that it may increase levothyroxine metabolism. Levothyroxine is used for the treatment of thyroid hormone deficiency, and rarely for the prevention of thyroid cancer recurrence. Vitamin K is a cofactor for the carboxylation reactions of glutamate residues of vitamin K-dependent proteins, so this inhibition limits the gamma-carboxylation reactions and activation of the vitamin K-dependent coagulant proteins.
Drug interactions with levothyroxine oral and warfarin oral
The lack of an interaction between levothyroxine and warfarin does not mean that patients receiving both drugs will not experience a change in their response to warfarin.
When the hypothyroidism is corrected by the levothyroxine the warfarin response returns to normal and the blood becomes too thin; life threatening bleeding has occurred from this series of events. Unknown No information available. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications.
It is not clear whether going from euthyroid to hyperthyroid would have the same effect on warfarin response as going from hypothyroid to euthyroid, but it cannot be ruled out with current data. Clin Pediatr Phila Mar;23 3: